How Does IontoPatch Work? Iontophoresis Explained

by Service, Training and Support·October 28, 2025

Iontopatch

IontoPatch is a single-use, self-contained iontophoresis device that uses a low-level direct electrical current to help move an appropriately charged medication through intact skin. Instead of connecting the patient to a reusable dose controller and lead wires, IontoPatch combines its power source, positive chamber, negative chamber, and adhesive system in one wearable patch.

The process begins when a healthcare professional places the prescribed ionic medication in the chamber having the same electrical polarity as the medication. Saline is placed in the opposite chamber according to the product instructions. Once both moistened chambers contact the skin, the electrical circuit is completed and current begins to flow.

The basic principle is “like charges repel.” A negatively charged medication is repelled by the patch’s negative electrode, while a positively charged medication is repelled by its positive electrode. That electrical force helps move the medication away from the chamber and across the skin. Iontophoresis transport can also be influenced by electroosmosis and temporary changes in skin permeability.

Compare the current IontoPATCH STAT, IontoPATCH 80, and IontoPatch Extra Strength models, or browse our complete iontophoresis product collection.

How IontoPatch Works in Seven Steps

StepWhat happens
1. Patient and medication screeningThe clinician determines whether iontophoresis is appropriate and verifies the medication, concentration, ionic charge, dose and treatment site
2. Skin preparationHair is trimmed when necessary, and intact skin is cleaned with soap and water and dried completely
3. Medication chamber preparationThe prescribed medication is placed in the chamber matching its electrical polarity
4. Opposite chamber activationSaline is placed in the opposite chamber according to the product instructions
5. Patch placementThe medicated chamber is positioned over the clinician-identified treatment site
6. Electrical deliverySkin contact completes the circuit, allowing the built-in power system to generate current
7. Dose completion and removalCurrent declines as the electrode coatings are consumed; the patch is removed after the instructed wear period and discarded

The patch contains no medication when packaged. Medication is supplied separately and added at the time of application. The saline supplied with the system is an activation solution rather than an active drug.

What Is Iontophoresis?

Iontophoresis is a method of electrically assisted transdermal drug delivery. It uses direct current to enhance the movement of suitable ionic compounds through the skin without a hypodermic needle.

The skin’s outermost layer, the stratum corneum, is an effective protective barrier. Passive medication movement through this barrier can be slow or limited. Iontophoresis adds electrical energy that can increase transport through pathways that include the following:

  • Sweat ducts
  • Hair follicles
  • Sebaceous glands
  • Intercellular and transcellular routes through the skin
  • Other microscopic aqueous pathways

Iontophoresis does not physically inject medication or puncture the skin. It enhances transport across intact skin by applying an electrical field. The FDA database identifies IontoPatch under the device classification for iontophoresis devices used to administer soluble salts or other ions for medical purposes.

Passive Diffusion vs. Iontophoresis

FeaturePassive topical applicationIontophoresis
Main driving forceNatural concentration gradientConcentration gradient plus electrical forces
Electrical currentNoYes
Best-suited compoundsDepends on skin permeability and formulationWater-soluble compounds with suitable ionic characteristics
Medication polarity requiredNot for ordinary passive diffusionYes, when electrorepulsion is being used
Skin punctureNoNo
Delivery controlPrimarily formulation-dependentInfluenced by current, time, formulation, skin and device design
External equipmentNone for a standard topical productPatch or iontophoresis controller required
Medication included with IontoPatchNot applicableNo, supplied separately

The Three Main Mechanisms of Iontophoretic Transport

The phrase “like repels like” explains the most familiar iontophoresis mechanism, but transdermal transport is more complex. Research describes three interacting mechanisms.

1. Electrorepulsion

Electrorepulsion is the direct force applied to a charged medication molecule by an electrode having the same polarity.

  • A negative electrode repels negatively charged ions.
  • A positive electrode repels positively charged ions.
  • The medication is moved away from the electrode and toward the skin.

This mechanism is also called electromigration. Its contribution depends on the compound’s charge, concentration, mobility, molecular size, and competition from other ions in the solution.

2. Electroosmosis

Human skin generally has a net negative charge under physiological conditions. When electrical current is applied, movement of ions can create a flow of solvent through charged skin pathways.

This bulk fluid movement is called electroosmosis. It generally favors movement from the positive electrode toward the negative electrode and can contribute to the transport of positively charged and some neutral polar compounds. Its importance varies with the medication, formulation, pH, and electrical conditions.

3. Current-Induced Changes in Skin Permeability

Passing current through the skin can temporarily alter the resistance and permeability of certain transport pathways. This may contribute to increased movement of a suitable compound compared with passive application alone.

MechanismPlain-language explanationMost directly relevant to
ElectrorepulsionA charged electrode pushes away medication with the same chargeIonic medication
ElectroosmosisElectrical current causes solvent movement through charged skin pathwaysEspecially cations and some neutral polar compounds
Increased skin permeabilityCurrent temporarily changes the resistance of transport pathwaysOverall electrically assisted transport

These mechanisms can occur together. Their relative contribution is not identical for every drug, patient, or treatment location.

Why Medication Polarity Matters

Medication polarity determines which IontoPatch chamber receives the prescribed solution.

Medication chargeChamber usedElectrical principle
Negative anionNegative chamberThe negative electrode repels the negative ion
Positive cationPositive chamberA positive electrode repels the positive ion
Neutral or non-ionized compoundNot efficiently driven by simple electrorepulsionSuitability must be evaluated by the clinician or pharmacist
Unknown polarityDo not guessConfirm with the prescriber, pharmacist or reliable drug information

Dexamethasone sodium phosphate is commonly discussed in rehabilitation iontophoresis as a negatively charged medication and is therefore generally placed in the negative chamber under the applicable protocol. That example should not be used to infer the polarity of unrelated medications.

The prescribing professional must confirm:

  • The exact medication and formulation
  • Whether it is water-soluble and ionized in solution
  • Its relevant electrical polarity
  • The concentration and volume
  • Whether the formulation is appropriate for transdermal iontophoresis
  • The required electrical dose
  • The treatment location and schedule

Non-ionized substances should not be assumed suitable merely because a related ionic compound exists.

For a broader review of medication and polarity concepts, read Balego’s Iontophoresis Frequently Asked Questions.

What Does the Saline Do?

Saline is placed in the chamber opposite the medication chamber according to current IontoPatch instructions. Its main function is to moisten the chamber, supply conductive ions, and help complete the electrical circuit when the patch contacts the skin.

Saline does not:

  • Serve as the prescribed medication
  • Determine the medication’s polarity
  • Increase the prescribed drug concentration
  • Mean that the entire supplied vial should be used
  • Turn an unsuitable non-ionic substance into an iontophoretic medication

Current application instructions say to fill the appropriate medication chamber with the model-specific medication volume, apply saline to the opposite chamber, leave an approximately 3 mm border around the chamber edges, and discard unused saline. Overfilling can allow fluid to spread toward the adhesive and compromise patch contact.

IontoPatch Fill Volumes

ModelMedication fill volumeDose capacityAverage wear time
IontoPATCH STAT1.0 mL80 mA·minAbout 4 hours
IontoPATCH 801.3 mL80 mA·minAbout 14 hours
IontoPatch Extra Strength1.0 mL120 mA·minAbout 8 hours

These are model specifications, not instructions to select a medication volume or patch without clinician direction. Current materials list these dose, fill-volume, and average wear-time differences.

How the Self-Contained IontoPatch Battery Works

IontoPatch does not require a rechargeable controller, replaceable battery pack, or external lead wires. Its power-producing components are built into the disposable patch.

Coated electrode surfaces that participate in electrochemical reactions:

  • Zinc is oxidized at the positive electrode.
  • Silver chloride is reduced at the negative electrode.
  • These reactions generate electrical potential.
  • Some models include an integrated 3-volt battery to increase the total potential.
  • Current begins when the moistened chambers contact the patient’s skin.
  • The available electrode coating is gradually consumed as treatment continues.
  • Current substantially declines after the coating capacity has been used.

Does IontoPatch Have an On/Off Button?

No separate power button is required.

The patch is activated by a combination of:

  1. Moistening the two chambers correctly
  2. Applying them securely to the skin
  3. Completing the electrical path between the positive and negative sides

This is why IontoPatch should not be filled far in advance of application or handled as though it were an ordinary passive adhesive bandage.

How Does IontoPatch Stop?

The manufacturer applies controlled amounts of reactive electrode coating during production. As treatment progresses, those materials are consumed, and current declines.

This provides a built-in electrical dose capacity, but the phrase "automatic shutoff" should be understood carefully. It means that current diminishes as the patch’s electrochemical capacity is exhausted. It does not mean the patch measures the exact number of drug molecules that entered a particular patient’s tissue.

What Does an 80 mA·min Dose Mean?

The iontophoresis dose is commonly expressed in milliamp-minutes:

Electrical dose = current in milliamps × time in minutes

Examples:

CurrentTreatment timeElectrical dose
4 mA20 minutes80 mA·min
2 mA40 minutes80 mA·min
1 mA80 minutes80 mA·min
0.25 mA320 minutes80 mA·min

These examples demonstrate the mathematics only. They are not IontoPatch programming instructions.

Two devices can provide the same total mA·min dose while using very different current levels and treatment durations. This explains how IontoPATCH STAT and IontoPATCH 80 can both be rated at 80 mA·min even though their average wear times differ substantially.

ModelElectrical doseDelivery strategy
IontoPATCH STAT80 mA·minHigher average current over a shorter wear period
IontoPATCH 8080 mA·minLower average current over a longer wear period
IontoPatch Extra Strength120 mA·minHigher total electrical capacity with an intermediate wear period

Technical information estimates the average current near 0.36 mA for STAT and approximately 0.26 mA for Extra Strength under the conditions described in its testing. Actual current and wear time vary because skin does not behave like a fixed resistor.

Electrical Dose Is Not the Same as Medication Dose

One of the most important points for clinicians, patients, and product-content writers is that mA·min describes electrical charge delivery—not a guaranteed number of milligrams delivered into tissue.

The amount of medication transported can be affected by:

  • The medication’s ionic charge
  • Concentration
  • Molecular size
  • Ionic mobility
  • Water solubility
  • pH and formulation
  • Competing ions
  • Fill volume
  • Skin resistance
  • Skin hydration
  • Treatment location
  • Sweat-duct density
  • Quality of patch contact
  • Duration of wear
  • Individual patient variation

Only part of the electrical current may be carried by the intended medication ion. Other ions in the formulation, saline, skin, and body fluids can also carry charge. Researchers refer to the portion attributable to the intended ion as its transport number or delivery efficiency.

Terms That Should Not Be Used Interchangeably

TermWhat it means
80 mA·minThe patch’s labeled electrical dose capacity
120 mA·minA higher electrical dose capacity
1.0 or 1.3 mLLiquid volume placed in the medication chamber
Drug concentrationAmount of medication per unit of solution
Medication loadedAmount placed in the patch chamber
Medication transportedA portion moved from the patch through the skin
Tissue concentrationAmount ultimately present at a sampled tissue location
Systemic exposureMedication that reaches circulation and may produce body-wide effects
IontoPatch is manufactured with a controlled electrical dose capacity. Actual medication transport varies according to the drug formulation, skin and treatment conditions.

Why Wear Time Varies Between Patients

Average wear times are not guarantees that every patch finishes at the exact same minute.

Skin resistance varies according to the following:

  • Skin thickness
  • Hydration
  • Cleanliness
  • Temperature
  • Treatment location
  • Sweat-pore density
  • Contact pressure
  • Adhesion
  • Individual physiology

Ohm’s law states:

Voltage = current × resistance

When voltage is relatively fixed, a higher electrical resistance generally results in lower current and a longer delivery time. Lower resistance may allow more current to flow and may shorten the time required to use the patch’s electrical capacity. Biological skin is nonlinear, however, and resistance can change during treatment.

Average Delivery Windows

ModelAverage dose-delivery timeCurrent substantially reduced after
IontoPATCH STATAbout 4 hoursAbout 6 hours
IontoPATCH 80About 14 hoursAbout 24 hours
IontoPatch Extra StrengthAbout 8 hoursManufacturer materials differ: follow the current package instructions and clinician direction

IontoPatch Model Comparison

FeatureIontoPATCH STATIontoPATCH 80IontoPatch Extra Strength
Electrical dose80 mA·min80 mA·min120 mA·min
Average wear timeAbout 4 hoursAbout 14 hoursAbout 8 hours
Medication volume1.0 mL1.3 mL1.0 mL
Active area12.0 cm²15.5 cm²12.0 cm²
Main distinctionShortest IontoPatch wear timeLower-current, extended-wear optionHigher electrical dose per patch
Common positioningShorter scheduling windowSensitive or fair skin and comfort-focused deliveryHigher-dose protocol when prescribed
External wiresNoNoNo
External controllerNoNoNo
Medication includedNoNoNo
Single-useYesYesYes

STAT and IontoPATCH 80 deliver the same labeled electrical dose but use different delivery profiles. Extra Strength increases the labeled electrical capacity by 50% compared with the two 80 mA·min models. Model selection should be based on the clinician’s prescribed dose, medication volume, treatment site, skin tolerance, and scheduling requirements—not on the assumption that faster or stronger is automatically better.

IontoPatch vs. Traditional Wired Iontophoresis

IontoPatch and a wired dose controller use the same broad therapeutic principle, but their workflows are different.

FeatureIontoPatchActivaDose II controller
Power sourceIntegrated into each patchReusable external controller
External lead wiresNoYes
Treatment electrodesIntegrated patch chambersSeparate drug and return electrodes
Current adjustmentDetermined by patch design and skin resistanceSet by the clinician
Dose selectionChoose an 80 or 120 mA·min patchProgram the prescribed dose up to the device limit
Treatment monitoringNo live displayCurrent, dose and time can be monitored
Patient mobilityDesigned for wearable useThe patient remains connected during treatment
Typical treatment settingApplied in clinic and worn as directedUsually supervised in a clinic
Reusable hardwareNoThe controller is reusable
Single-use componentsEntire patchElectrode kit
Best fitConvenience, mobility and self-contained deliveryDirect control and real-time supervision

A wired system may be preferred when the clinician wants to adjust the current, observe the entire treatment, or stop and modify the session immediately. A wearable patch may be preferred when the prescribed dose and treatment location are compatible with a self-contained extended-wear format.

Explore compatible wired options such as the ActivaDose II Dose Controller, Trivarion iontophoresis electrode kits, and Ionto4 iontophoresis electrodes.

IontoPatch vs. ACTIVApatch

Both product families provide self-contained wearable iontophoresis, but their available treatment times and activation systems differ.

FeatureIontoPatchACTIVApatch
ModelsSTAT, 80, Extra StrengthIntelliDose 2.5, IontoGo 4.0, IontoGo 12.0
Dose options80 or 120 mA·min40 or 80 mA·min
Approximate treatment windows4, 8 or 14 hours1.25, 2.5, 4 or 12 hours
Saline activationYes, according to IontoPatch instructionsCurrent Balego-listed models do not require saline
External controllerNoNo
External wiresNoNo
Visual feedbackNo active status displayIntelliDose includes LED status feedback
Automatic dose-ending designElectrode capacity becomes depletedModel-dependent microprocessor or shunt technology
Medication includedNoNo
Best distinction120 mA·min option and established three-model IontoPatch familyFaster IntelliDose options and no-saline workflow

Neither product family should be selected solely by treatment speed. The clinician should compare the prescribed electrical dose, medication volume, treatment site, skin sensitivity, application workflow, and the product’s current instructions.

How to Apply IontoPatch Correctly

1. Confirm the Prescription and Polarity

Verify the medication, concentration, ionic polarity, electrical dose, patch model, and treatment location. Do not infer polarity from a drug’s brand name or from another medication in the same category.

2. Inspect the Skin

Apply only to a clinician-approved area of intact skin. Do not place the patch over damaged or denuded skin or around the orbital region. Ask about medication allergies and sensitivities before treatment.

3. Prepare the Area

  • Trim excess hair when needed.
  • Wash the site with soap and water.
  • Dry it completely.
  • Do not use an alcohol wipe for routine IontoPatch preparation; current manufacturer instructions state that alcohol may dry and irritate the skin.

4. Fill the Correct Chamber

Place the prescribed medication in the chamber matching the medication’s charge:

  • Negative medication → negative chamber
  • Positive medication → positive chamber

Use the model-specific fill volume and leave the recommended border around the chamber. Do not overfill.

5. Add Saline to the Opposite Chamber

Use enough saline to prepare the opposite chamber as instructed. The full supplied amount is not necessarily required, and unused saline should be discarded.

6. Position the Joint

Place the joint approximately midway through its comfortable range of motion. This reduces the likelihood that the adhesive will be pulled excessively when the joint later bends or straightens.

7. Place the Medicated Chamber Over the Target

The clinician-selected medication chamber—not simply the center of the overall patch—should be positioned over the treatment site.

8. Secure the Perimeter

Run a finger around the outside adhesive edge. Do not press firmly on the center of the fluid-filled chambers during initial placement because this may force liquid toward the adhesive and weaken the seal.

Read our IontoPatch Application Quick-Start Guide for additional setup guidance.

What Happens While the Patch Is Being Worn?

Once applied:

  • The skin completes the circuit.
  • Current begins flowing between the two chambers.
  • Charged medication is driven from the corresponding electrode.
  • Electrical delivery continues gradually over several hours.
  • Current varies with skin resistance and treatment conditions.
  • The electrode capacity is consumed over time.
  • Current declines as the available electrochemical material is depleted.

Most patients feel little or no sensation. Some may notice mild tingling or tugging. Strong burning, sharp pain, or progressively worsening discomfort is not something to ignore. Remove the patch with soap and water and contact the healthcare provider when an unusual reaction develops.

For additional guidance, read the following:

Can Medication Remain Localized?

IontoPatch supports localized transdermal administration over a selected treatment area, but some medication may enter systemic circulation depending on the compound and treatment conditions.

Can IontoPatch Deliver Two Medications at Once?

The two-chamber design can theoretically support simultaneous delivery of appropriately selected positive and negative compounds by placing each in its corresponding chamber. The manufacturer describes this technical capability.

That does not mean two medications should routinely be combined. The prescriber and pharmacist would need to evaluate the following:

  • Each medication’s charge
  • Compatibility
  • Concentration
  • Total dose
  • Interactions
  • Stability
  • Competing-ion effects
  • Patient-specific risk
  • Whether the intended treatment is supported by labeling and clinical judgment

Saline in the return chamber remains the standard workflow described in current application instructions.

How Is IontoPatch Different From TENS or NMES?

IontoPatch, TENS and NMES all involve electricity applied through the skin, but they serve different purposes.

FeatureIontoPatchTENSNMES/EMS
Primary objectiveAssist transdermal delivery of ionic medicationSensory nerve stimulation for temporary pain-modulation supportMotor-nerve stimulation and muscle contraction
Medication usedYes, when prescribedNoNo
Intended sensationOften little or no sensationNoticeable sensory tinglingMuscle contraction
Current typeLow-level direct-current iontophoresisPulsed stimulationPulsed stimulation
External controllerNoUsually yesUsually yes
Electrode functionMedication and return chambersDeliver sensory stimulationDeliver motor-level stimulation
Interchangeable treatmentNoNoNo

A TENS or NMES unit does not become an iontophoresis device merely because it delivers electrical current. Iontophoresis requires a device and electrode system specifically intended for drug-delivery applications.

Safety and Use Considerations

TopicGuidance
MedicationUse only the medication, formulation and concentration directed by the prescriber
PolarityConfirm the medication’s ionic charge before filling the patch
SkinApply to clean, intact skin
Damaged skinContraindicated over damaged or denuded skin
Orbital regionDo not treat around the eyes
AllergiesReview medication and adhesive sensitivities
SensationMild tingling may occur; unusual burning or pain should be reported
PressureDo not wrap tightly or apply prolonged excessive pressure
WaterAvoid immersion; minimize direct shower exposure
MRIRemove IontoPatch before an MRI procedure
ReuseSingle-use only
Medication effectsLocal and systemic adverse effects are possible
RemovalLoosen slowly with soap and water
DisposalFold the chambers together and dispose of the used patch according to instructions and applicable policy

The device is FDA-cleared as an iontophoresis device, but FDA clearance should not be described as approval of every medication, diagnosis, placement, or treatment protocol.

Frequently Asked Questions

How does IontoPatch push medication through the skin?

The patch creates a low-level electrical field. A medication ion is placed under an electrode with the same charge, causing the medication to be repelled away from that chamber. Electroosmosis and current-related changes in skin permeability may also contribute to transport.

Does IontoPatch have a battery?

Yes. Its power-producing system is incorporated into the disposable patch. Depending on the model, electrode coatings and an integrated thin battery provide the electrical potential needed for current flow. No external battery pack is required.

When does IontoPatch turn on?

Current begins when the medication and saline chambers are prepared and the moistened patch is applied securely to the skin, completing the circuit.

Does the IontoPatch automatically shut off?

Current diminishes as the patch’s controlled electrode capacity is consumed. It is more accurate to say that the patch has a self-limiting electrical dose capacity than to imply that it directly measures tissue medication levels.

Does IontoPatch contain medication?

No. Medication is supplied separately and added at the time of treatment.

Why is saline used?

Saline moistens the opposite chamber, supplies conductive ions, and helps complete the circuit. It is not the active medication.

Which side does dexamethasone go on?

Dexamethasone sodium phosphate is generally treated as negatively charged in common iontophoresis protocols and placed in the negative chamber. The exact formulation and polarity must still be confirmed by the clinician or pharmacist.

What does 80 mA·min mean?

It is an electrical dose equal to current in milliamps multiplied by treatment time in minutes. It is not the same as 80 mg of medication.

Do STAT and IontoPATCH 80 deliver different doses?

Both have an 80 mA·min electrical capacity. STAT delivers it over an average of about four hours, while IontoPATCH 80 uses a lower-current profile over approximately fourteen hours.

Is Extra Strength just a faster version of STAT?

No. Extra Strength has a larger 120 mA·min electrical dose capacity and an average wear time of about eight hours. STAT provides 80 mA·min over approximately four hours.

Does a higher mA·min rating mean more medication always enters the body?

Not necessarily. A higher electrical dose can increase the opportunity for ionic transport, but actual delivery also depends on the compound, concentration, formulation, competing ions, skin, and treatment conditions.

Can I fill the patch with any liquid medication?

No. The compound must be suitable for iontophoresis, and its formulation, charge, concentration, and clinical use must be verified. Non-ionized or poorly soluble compounds may not be delivered effectively.

Why should I not use an alcohol wipe?

Current manufacturer application guidance recommends soap and water and states that alcohol can dry and irritate the skin.

Can I exercise while wearing IontoPatch?

The patch is designed to accommodate normal movement and weight-bearing activity when the exercise is medically appropriate and the patch remains secure. Avoid friction, immersion, and excessive compression.

Can I shower with IontoPatch?

Minimize direct water exposure and gently pat the patch dry if it becomes wet. Do not immerse it in bathwater or while swimming.

What should I do if IontoPatch burns?

Remove the patch slowly with soap and water, clean and inspect the skin, and notify the healthcare provider. Strong burning, significant pain, blistering, or another abnormal reaction should not be tolerated.

Can the patch be reused?

No. It is a disposable, single-use device. Once removed, it should not be refilled or reapplied.

Is IontoPatch the same as an ordinary medicated patch?

No. A conventional passive patch releases medication primarily through diffusion. IontoPatch uses an electrical field to enhance the transport of suitable ionic medication.

Is IontoPatch supported by clinical research?

A randomized trial directly evaluated an earlier self-contained IontoPatch protocol for dexamethasone delivery in lateral epicondylitis. It reported selected short-term advantages, while measured outcomes were similar among groups at six months. Read our IontoPatch Evidence-Based Research review.

The Bottom Line

IontoPatch works by combining a positive chamber, a negative chamber, and a self-contained power source in one disposable adhesive device. The clinician places an appropriately charged medication in the chamber having the same polarity and saline in the opposite chamber. Skin contact completes the circuit, and the electrical field helps transport the medication through electrorepulsion, electroosmosis, and current-related changes in skin permeability.

The patch is manufactured with a controlled electrical capacity expressed in mA·min. It does not directly measure the exact amount of medication reaching a patient’s tissue, and actual transport varies with the medication, formulation, skin resistance, and application conditions.

The three current models provide different treatment profiles:

The prescribing professional should determine the medication, polarity, electrical dose, patch model, treatment site, and wear schedule. IontoPatch should be used as a clinician-directed drug-delivery device—not as an ordinary pain patch or a self-selected substitute for prescription medication, injection, or rehabilitation.

Related Balego Resources

Medical and Professional-Use Notice

IontoPatch is intended for clinician-directed iontophoresis drug-delivery applications. Medication selection, formulation, concentration, polarity, electrical dose, patch model, treatment location, wear time, and treatment frequency should be determined by an appropriately licensed healthcare professional.

This article provides general product education. It does not recommend a medication, establish a treatment protocol, guarantee the amount of medication delivered, replace medication labeling, or supersede the current manufacturer instructions.